Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM50386556 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_826202 (CHEMBL2049643) |
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IC50 | >100000±n/a nM |
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Citation | Lin, YS; Park, J; De Schutter, JW; Huang, XF; Berghuis, AM; Sebag, M; Tsantrizos, YS Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. J Med Chem55:3201-15 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM50386556 |
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n/a |
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Name | BDBM50386556 |
Synonyms: | CHEMBL2048242 |
Type | Small organic molecule |
Emp. Form. | C16H20N2O7P2 |
Mol. Mass. | 414.2867 |
SMILES | OP(O)(=O)C(Nc1cc(ccn1)-c1ccc(OC2CCC2)cc1)P(O)(O)=O |
Structure |
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