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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | P2X purinoceptor 7 | ||
| Ligand | BDBM50386568 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_826226 (CHEMBL2049237) | ||
| IC50 | 130±n/a nM | ||
| Citation |  Lee, WG; Lee, SD; Cho, JH; Jung, Y; Kim, JH; Hien, TT; Kang, KW; Ko, H; Kim, YC Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists. J Med Chem55:3687-98 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| P2X purinoceptor 7 | |||
| Name: | P2X purinoceptor 7 | ||
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor | ||
| Type: | Protein | ||
| Mol. Mass.: | 68602.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99572 | ||
| Residue: | 595 | ||
| Sequence: |
| ||
| BDBM50386568 | |||
| n/a | |||
| Name | BDBM50386568 | ||
| Synonyms: | CHEMBL2048436 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H19Cl2N3O | ||
| Mol. Mass. | 340.248 | ||
| SMILES | Clc1cncc(Cl)c1NNC(=O)C1C2CC3CC(C2)CC1C3 |TLB:10:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(.23,-.82,;1.57,-1.59,;1.57,-3.13,;2.9,-3.9,;4.24,-3.13,;4.23,-1.58,;5.56,-.8,;2.9,-.82,;2.89,.72,;4.22,1.5,;4.22,3.04,;2.88,3.8,;5.55,3.81,;6.95,3.33,;7.76,1.77,;7.86,3.33,;8.86,4.47,;7.99,5.85,;7.86,4.42,;6.56,6.37,;5.55,5.24,;6.37,3.85,)| | ||
| Structure | 
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