Ki Summary

Reaction Details

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Target

Free fatty acid receptor 1

Ligand

BDBM50386652

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_826835 (CHEMBL2051552)

58±n/a nM

Citation

Mikami, S; Kitamura, S; Negoro, N; Sasaki, S; Suzuki, M; Tsujihata, Y; Miyazaki, T; Ito, R; Suzuki, N; Miyazaki, J; Santou, T; Kanzaki, N; Funami, M; Tanaka, T; Yasuma, T; Momose, Y Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem55:3756-76 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Free fatty acid receptor 1

Name:

Free fatty acid receptor 1

Synonyms:

FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

31473.32

Organism:

Homo sapiens (Human)

Description:

O14842

Residue:

300

Sequence:

MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLP
LKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRP
CYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAG
PARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPY
NASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK

BDBM50386652

n/a

Name

BDBM50386652

Synonyms:

CHEMBL2048610

Type

Small organic molecule

Emp. Form.

C25H26O3

Mol. Mass.

374.4721

SMILES

Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1C |(-7.65,4.87,;-7.65,3.33,;-8.98,2.56,;-8.98,1.01,;-7.65,.24,;-6.31,1.02,;-4.97,.25,;-6.31,2.57,;-4.99,3.34,;-5,4.87,;-3.67,5.65,;-2.33,4.89,;-2.32,3.34,;-.99,2.58,;.35,3.35,;1.68,2.59,;1.68,1.05,;3.01,.28,;4.35,1.06,;5.68,.29,;7.01,1.07,;8.35,.31,;8.36,-1.24,;9.69,1.08,;4.34,2.6,;3,3.36,;-3.65,2.57,;-3.65,1.03,)|

Structure