| Reaction Details |
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 | Report a problem with these data |
| Target | Quinolone resistance protein NorA |
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| Ligand | BDBM50386656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826866 (CHEMBL2051681) |
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| IC50 | 10000±n/a nM |
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| Citation |  Sabatini, S; Gosetto, F; Serritella, S; Manfroni, G; Tabarrini, O; Iraci, N; Brincat, JP; Carosati, E; Villarini, M; Kaatz, GW; Cecchetti, V Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors. J Med Chem55:3568-72 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Quinolone resistance protein NorA |
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| Name: | Quinolone resistance protein NorA |
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| Synonyms: | NORA_STAAU | norA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42273.03 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_961221 |
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| Residue: | 388 |
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| Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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| BDBM50386656 |
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| n/a |
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| Name | BDBM50386656 |
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| Synonyms: | CHEMBL2048632 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H13ClN4O4S |
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| Mol. Mass. | 452.87 |
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| SMILES | [O-][N+](=O)c1ccc(cc1)-n1nc(c2NS(=O)(=O)c3ccccc3-c12)-c1ccc(Cl)cc1 |
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| Structure | 
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