| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM50386816 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_828458 (CHEMBL2049895) |
|---|
| IC50 | >5000±n/a nM |
|---|
| Citation |  Vijay Kumar, D; Hoarau, C; Bursavich, M; Slattum, P; Gerrish, D; Yager, K; Saunders, M; Shenderovich, M; Roth, BL; McKinnon, R; Chan, A; Cimbora, DM; Bradford, C; Reeves, L; Patton, S; Papac, DI; Williams, BL; Carlson, RO Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors. Bioorg Med Chem Lett22:4377-85 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM50386816 |
|---|
| n/a |
|---|
| Name | BDBM50386816 |
|---|
| Synonyms: | CHEMBL2047943 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29N7O |
|---|
| Mol. Mass. | 407.512 |
|---|
| SMILES | Cc1cc(ccc1Nc1nc(NC2CCCCC2)c2[nH]cnc2n1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
