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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50386853
Substrate/Competitorn/a
Meas. Tech.ChEMBL_828470 (CHEMBL2049907)
EC50 8.30±n/a nM
Citation Buzard, DJHan, SLopez, LKawasaki, AMoody, JThoresen, LUllman, BLehmann, JCalderon, IZhu, XGharbaoui, TSengupta, DKrishnan, AGao, YEdwards, JBarden, JMorgan, MUsmani, KChen, CSadeque, AThatte, JSolomon, MFu, LWhelan, KLiu, LAl-Shamma, HGatlin, JLe, MXing, CEspinola, SJones, RM Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett22:4404-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:Edg1 | Lpb1 | S1PR1_MOUSE | S1pr1 | Sphingosine 1-phosphate receptor 1 | Sphingosine 1-phosphate receptor 1 (S1P1)
Type:Enzyme
Mol. Mass.:42663.66
Organism:Mus musculus (Mouse)
Description:O08530
Residue:382
Sequence:
MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM
GWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS
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BDBM50386853
n/a
NameBDBM50386853
Synonyms:CHEMBL2048287
TypeSmall organic molecule
Emp. Form.C23H15F3N4O4
Mol. Mass.468.3848
SMILESOC(=O)CC1CCc2c1[nH]c1ccc(cc21)-c1noc(n1)-c1cc(OC(F)(F)F)cc(c1)C#N
Structure
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