| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM50078329 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827550 (CHEMBL2051578) |
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| IC50 | 490±n/a nM |
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| Citation |  Li, Y; Silamkoti, A; Kolavi, G; Mou, L; Gulati, S; Air, GM; Brouillette, WJ Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity. Bioorg Med Chem20:4582-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | NA | NRAM_I72A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52146.22 |
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| Organism: | Influenza A virus (strain A/Udorn/307/1972 H3N2) |
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| Description: | ChEMBL_882379 |
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| Residue: | 469 |
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| Sequence: | MNPNQKIITIGSVSLTIATICFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIER
NITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRTPHRTLLMNELGVPFHLGTRQVCIAWSS
SSCHDGKAWLHVCVTGYDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTKILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNR
PVVDINVKDYSIDSSYVCSGLVGDTPRNNDRSSNSYCRNPNNEKGNHGVKGWAFDDGNDV
WMGRTISEDSRSGYETFKVIGGWSTPNSKLQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
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| BDBM50078329 |
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| n/a |
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| Name | BDBM50078329 |
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| Synonyms: | 1-[4-CARBOXY-2-(3-PENTYLAMINO)PHENYL]-5,5'-DI(HYDROXYMETHYL)PYRROLIDIN-2-ONE | 1-[4-carboxy-2-(3-pentylamino)phenyl]-5,5-bis(hydroxymethyl)pyrrolidin-2-one | 4-[2,2-bis(hydroxymethyl)-5-oxopyrrolidin-1-yl]-3-[(1-ethylpropyl)amino]benzoic acid | CHEMBL307189 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H26N2O5 |
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| Mol. Mass. | 350.4094 |
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| SMILES | CCC(CC)Nc1cc(ccc1N1C(=O)CCC1(CO)CO)C(O)=O |
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| Structure | 
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