Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase 3 |
---|
Ligand | BDBM50387330 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_828111 (CHEMBL2049850) |
---|
IC50 | >2000±n/a nM |
---|
Citation | Jimenez, JM; Davis, C; Boyall, D; Fraysse, D; Knegtel, R; Settimo, L; Young, S; Bolton, C; Chiu, P; Curnock, A; Rasmussen, R; Tanner, A; Ager, I Structure-based optimization of aminopyridines as PKC¿ inhibitors. Bioorg Med Chem Lett22:4645-9 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 3 |
---|
Name: | Mitogen-activated protein kinase 3 |
Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
Type: | Protein |
Mol. Mass.: | 43136.58 |
Organism: | Homo sapiens (Human) |
Description: | curated by PDB 4QTB |
Residue: | 379 |
Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
|
|
|
BDBM50387330 |
---|
n/a |
---|
Name | BDBM50387330 |
Synonyms: | CHEMBL2046643 |
Type | Small organic molecule |
Emp. Form. | C20H24F3N5O |
Mol. Mass. | 407.4327 |
SMILES | CC(C)C[C@H]1CN(CCN1)c1ccc(c(n1)C(=O)c1cccnc1N)C(F)(F)F |r| |
Structure |
|