Reaction Details |
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Target | Lysine--tRNA ligase |
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Ligand | BDBM50387330 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_828112 (CHEMBL2049851) |
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Ki | >4000±n/a nM |
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Citation | Jimenez, JM; Davis, C; Boyall, D; Fraysse, D; Knegtel, R; Settimo, L; Young, S; Bolton, C; Chiu, P; Curnock, A; Rasmussen, R; Tanner, A; Ager, I Structure-based optimization of aminopyridines as PKC¿ inhibitors. Bioorg Med Chem Lett22:4645-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine--tRNA ligase |
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Name: | Lysine--tRNA ligase |
Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 68044.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_960665 |
Residue: | 597 |
Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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BDBM50387330 |
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n/a |
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Name | BDBM50387330 |
Synonyms: | CHEMBL2046643 |
Type | Small organic molecule |
Emp. Form. | C20H24F3N5O |
Mol. Mass. | 407.4327 |
SMILES | CC(C)C[C@H]1CN(CCN1)c1ccc(c(n1)C(=O)c1cccnc1N)C(F)(F)F |r| |
Structure |
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