| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50387412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_828286 (CHEMBL2050305) |
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| IC50 | >13000±n/a nM |
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| Citation |  Gangjee, A; Zhao, Y; Ihnat, MA; Thorpe, JE; Bailey-Downs, LC; Kisliuk, RL Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem20:4217-25 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50387412 |
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| n/a |
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| Name | BDBM50387412 |
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| Synonyms: | CHEMBL2047252 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClFN4 |
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| Mol. Mass. | 326.755 |
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| SMILES | Nc1nc2cc3ccccc3c2c(Nc2ccc(F)c(Cl)c2)[nH]1 |
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| Structure | 
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