| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
|---|
| Ligand | BDBM50387559 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_830331 (CHEMBL2060920) |
|---|
| IC50 | 68.89±n/a nM |
|---|
| Citation |  Qian, W; Lu, W; Sun, H; Li, Z; Zhu, L; Zhao, R; Zhang, L; Zhou, S; Zhou, Y; Jiang, H; Zhen, X; Liu, H Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D1 receptor. Bioorg Med Chem20:4862-71 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(1A) dopamine receptor |
|---|
| Name: | D(1A) dopamine receptor |
|---|
| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49303.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P21728 |
|---|
| Residue: | 446 |
|---|
| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
|
|
|
|---|
| BDBM50387559 |
|---|
| n/a |
|---|
| Name | BDBM50387559 |
|---|
| Synonyms: | CHEMBL2057453 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21NO3 |
|---|
| Mol. Mass. | 311.3749 |
|---|
| SMILES | COc1ccc2CN3CCc4cc(OC)c(O)cc4[C@@H]3Cc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
