| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50387563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_830339 (CHEMBL2060973) |
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| IC50 | 11840±n/a nM |
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| Citation |  Qian, W; Lu, W; Sun, H; Li, Z; Zhu, L; Zhao, R; Zhang, L; Zhou, S; Zhou, Y; Jiang, H; Zhen, X; Liu, H Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D1 receptor. Bioorg Med Chem20:4862-71 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 49303.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21728 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50387563 |
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| n/a |
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| Name | BDBM50387563 |
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| Synonyms: | CHEMBL2057446 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27NO5 |
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| Mol. Mass. | 385.4535 |
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| SMILES | COc1cc2C[C@@H]3N(CCc4cc(OC)c(OC)c(OC)c34)Cc2c(OC)c1 |r| |
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| Structure | 
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