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TargetPeptidyl-prolyl cis-trans isomerase FKBP5
LigandBDBM23334
Substrate/Competitorn/a
Meas. Tech.ChEMBL_829710
IC50>100000±n/a nM
Citation Gopalakrishnan RKozany CGaali SKress CHoogeland BBracher AHausch F Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem 55:4114-22 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP5
Name:Peptidyl-prolyl cis-trans isomerase FKBP5
Synonyms:51 kDa FK506-binding protein | 51 kDa FKBP | 54 kDa progesterone receptor-associated immunophilin | AIG6 | Androgen-regulated protein 6 | FF1 antigen | FK506-binding protein 5 | FKBP-5 | FKBP-51 | FKBP5 | FKBP51 | FKBP54 | HSP90-binding immunophilin | PPIase FKBP5 | Rotamase | p54
Type:PROTEIN
Mol. Mass.:51207.06
Organism:Homo sapiens (Human)
Description:ChEMBL_952910
Residue:457
Sequence:
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGK
LSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP
KIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRM
FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAE
LIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEM
EYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQD
AKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
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  Blast E-value cutoff:
BDBM23334
n/a
NameBDBM23334
Synonyms:3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate | CHEMBL6367 | GPI 1046
TypeSmall organic molecule
Emp. Form.C20H28N2O4
Mol. Mass.360.4473
SMILESCCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)OCCCc1cccnc1 |r|
Structure
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