Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPeptidyl-prolyl cis-trans isomerase FKBP4
LigandBDBM50388321
Substrate/Competitorn/a
Meas. Tech.ChEMBL_829711 (CHEMBL2061151)
IC50 3720±n/a nM
Citation Gopalakrishnan, RKozany, CGaali, SKress, CHoogeland, BBracher, AHausch, F Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem55:4114-22 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP4
Name:Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:PROTEIN
Mol. Mass.:51793.87
Organism:Homo sapiens (Human)
Description:ChEMBL_154482
Residue:459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKD
KLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPN
AELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL
EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG
EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE
EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50388321
n/a
NameBDBM50388321
Synonyms:CHEMBL2059035
TypeSmall organic molecule
Emp. Form.C39H54N2O9
Mol. Mass.694.8541
SMILESCC[C@@H]1CCCC[C@@]1(O)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCCN2CCOCC2)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: