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TargetPeptidyl-prolyl cis-trans isomerase FKBP4
LigandBDBM50388323
Substrate/Competitorn/a
Meas. Tech.ChEMBL_829711 (CHEMBL2061151)
IC50 2640±n/a nM
Citation Gopalakrishnan, RKozany, CGaali, SKress, CHoogeland, BBracher, AHausch, F Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem55:4114-22 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP4
Name:Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:PROTEIN
Mol. Mass.:51793.87
Organism:Homo sapiens (Human)
Description:ChEMBL_154482
Residue:459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKD
KLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPN
AELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL
EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG
EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE
EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50388323
n/a
NameBDBM50388323
Synonyms:CHEMBL2059237
TypeSmall organic molecule
Emp. Form.C34H43NO10
Mol. Mass.625.7059
SMILESCOc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)CCCC[C@@H]2C)c2cccc(OCC(O)=O)c2)cc1OC |r|
Structure
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