| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50388438 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_829921 (CHEMBL2061569) |
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| Ki | 0.06±n/a nM |
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| Citation |  Flores, A; Sicinski, RR; Grzywacz, P; Thoden, JB; Plum, LA; Clagett-Dame, M; DeLuca, HF A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1a,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3. J Med Chem55:4352-66 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | Nr1i1 | VDR_RAT | Vdr | Vitamin D receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47811.07 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1505946 |
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| Residue: | 423 |
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| Sequence: | MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSL
RPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSS
SSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGF
AKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAG
HTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQ
TYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
EIS
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| BDBM50388438 |
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| n/a |
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| Name | BDBM50388438 |
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| Synonyms: | CHEMBL2059271 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H48O3 |
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| Mol. Mass. | 444.6896 |
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| SMILES | [#6]-[#6@H](-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)C([#6])([#6])[#6]-[#6]C([#6])([#6])[#8] |r| |
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| Structure | 
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