| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50388452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_829934 (CHEMBL2061639) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Kasai, S; Kamata, M; Masada, S; Kunitomo, J; Kamaura, M; Okawa, T; Takami, K; Ogino, H; Nakano, Y; Ashina, S; Watanabe, K; Kaisho, T; Imai, YN; Ryu, S; Nakayama, M; Nagisa, Y; Takekawa, S; Kato, K; Murata, T; Suzuki, N; Ishihara, Y Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities. J Med Chem55:4336-51 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39075.64 |
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| Organism: | RAT |
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| Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
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| Residue: | 353 |
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| Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50388452 |
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| n/a |
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| Name | BDBM50388452 |
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| Synonyms: | CHEMBL2059420 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N3O2 |
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| Mol. Mass. | 429.5539 |
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| SMILES | C[C@@H](N1CCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 |r| |
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| Structure | 
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