Ki Summary

Reaction Details

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Target

M-phase inducer phosphatase 2

Ligand

BDBM41999

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_830418 (CHEMBL2061096)

80±n/a nM

Citation

Lavecchia, A; Di Giovanni, C; Pesapane, A; Montuori, N; Ragno, P; Martucci, NM; Masullo, M; De Vendittis, E; Novellino, E Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening. J Med Chem55:4142-58 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

M-phase inducer phosphatase 2

Name:

M-phase inducer phosphatase 2

Synonyms:

Type:

Protein

Mol. Mass.:

64985.27

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

580

Sequence:

MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

BDBM41999

n/a

Name

BDBM41999

Synonyms:

3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic acid | 3-(3,4,5-trihydroxy-6-oxo-9-xanthenyl)propanoic acid | 3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)propanoic acid | 3-[3,4,5-tris(oxidanyl)-6-oxidanylidene-xanthen-9-yl]propanoic acid | MLS-0111617.0001 | cid_274127

Type

Small organic molecule

Emp. Form.

C16H12O7

Mol. Mass.

316.2623

SMILES

OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12

Structure