Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosyl-DNA phosphodiesterase 1
LigandBDBM50388544
Substrate/Competitorn/a
Meas. Tech.ChEMBL_830578 (CHEMBL2061433)
IC50 1900±n/a nM
Citation Nguyen, TXMorrell, AConda-Sheridan, MMarchand, CAgama, KBermingham, ABermingam, AStephen, AGChergui, ANaumova, AFisher, RO'Keefe, BRPommier, YCushman, M Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. J Med Chem55:4457-78 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosyl-DNA phosphodiesterase 1
Name:Tyrosyl-DNA phosphodiesterase 1
Synonyms:TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Type:Enzyme
Mol. Mass.:68430.66
Organism:Homo sapiens (Human)
Description:Q9NUW8
Residue:608
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50388544
n/a
NameBDBM50388544
Synonyms:CHEMBL2057323
TypeSmall organic molecule
Emp. Form.C41H36N4O4
Mol. Mass.648.7489
SMILESO=C1c2ccccc2-c2c1c1ccccc1c(=O)n2CCCNCCCNCCCn1c2-c3ccccc3C(=O)c2c2ccccc2c1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: