Reaction Details |
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Target | Smoothened homolog |
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Ligand | BDBM50388712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_829474 (CHEMBL2061994) |
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IC50 | 12±n/a nM |
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Citation | Yang, B; Hird, AW; Russell, DJ; Fauber, BP; Dakin, LA; Zheng, X; Su, Q; Godin, R; Brassil, P; Devereaux, E; Janetka, JW Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg Med Chem Lett22:4907-11 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Smoothened homolog |
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Name: | Smoothened homolog |
Synonyms: | G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog |
Type: | Protein |
Mol. Mass.: | 86415.51 |
Organism: | Homo sapiens (Human) |
Description: | Q99835 |
Residue: | 787 |
Sequence: | MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
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BDBM50388712 |
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n/a |
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Name | BDBM50388712 |
Synonyms: | CHEMBL2059870 |
Type | Small organic molecule |
Emp. Form. | C26H26N4O2 |
Mol. Mass. | 426.5102 |
SMILES | Cc1nn(C)c(C)c1-c1ccc(C)c(NC(=O)c2ccc(OCc3ccccn3)cc2)c1 |
Structure |
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