Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50153846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_829534 (CHEMBL2060772) |
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IC50 | 17±n/a nM |
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Citation | Yang, B; Hird, AW; Russell, DJ; Fauber, BP; Dakin, LA; Zheng, X; Su, Q; Godin, R; Brassil, P; Devereaux, E; Janetka, JW Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO. Bioorg Med Chem Lett22:4907-11 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50153846 |
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n/a |
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Name | BDBM50153846 |
Synonyms: | 4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido]-3-[4-(1,3-thiazol-4-ylmethoxy)phenylcarboxamido]benzene | CHEMBL183630 |
Type | Small organic molecule |
Emp. Form. | C29H28N4O4S |
Mol. Mass. | 528.622 |
SMILES | Cc1ccc(NC(=O)c2cccc(c2)N2CCOCC2)cc1NC(=O)c1ccc(OCc2cscn2)cc1 |
Structure |
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