| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 2 |
|---|
| Ligand | BDBM50388784 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_830911 (CHEMBL2065460) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Dowling, JE; Chuaqui, C; Pontz, TW; Lyne, PD; Larsen, NA; Block, MH; Chen, H; Su, N; Wu, A; Russell, D; Pollard, H; Lee, JW; Peng, B; Thakur, K; Ye, Q; Zhang, T; Brassil, P; Racicot, V; Bao, L; Denz, CR; Cooke, E Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett3:278-283 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Homeodomain-interacting protein kinase 2 |
|---|
| Name: | Homeodomain-interacting protein kinase 2 |
|---|
| Synonyms: | HIPK2 | HIPK2_HUMAN | Homeodomain-interacting protein kinase 2 | Homeodomain-interacting protein kinase 2 (HIPK2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 131001.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H2X6 |
|---|
| Residue: | 1198 |
|---|
| Sequence: | MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
|
|
|
|---|
| BDBM50388784 |
|---|
| n/a |
|---|
| Name | BDBM50388784 |
|---|
| Synonyms: | CHEMBL2062575 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24N8O |
|---|
| Mol. Mass. | 416.479 |
|---|
| SMILES | CN(C)CCCNc1cc(nc2c(cnn12)C#N)-n1ccc2ccc(NC(C)=O)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
