| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha |
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| Ligand | BDBM50388792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_830890 (CHEMBL2065439) |
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| IC50 | 18±n/a nM |
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| Citation |  Dowling, JE; Chuaqui, C; Pontz, TW; Lyne, PD; Larsen, NA; Block, MH; Chen, H; Su, N; Wu, A; Russell, D; Pollard, H; Lee, JW; Peng, B; Thakur, K; Ye, Q; Zhang, T; Brassil, P; Racicot, V; Bao, L; Denz, CR; Cooke, E Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett3:278-283 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha |
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| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 45151.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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| BDBM50388792 |
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| n/a |
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| Name | BDBM50388792 |
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| Synonyms: | CHEMBL2062576 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N8O |
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| Mol. Mass. | 442.5162 |
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| SMILES | CC(=O)Nc1ccc2ccn(-c3cc(NCCCN4CCCC4)n4ncc(C#N)c4n3)c2c1 |
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| Structure | 
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