| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50388921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_831086 (CHEMBL2065832) |
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| IC50 | 28±n/a nM |
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| Citation |  Serrano-Wu, MH; Coppola, GM; Gong, Y; Neubert, AD; Chatelain, R; Clairmont, KB; Commerford, R; Cosker, T; Daniels, T; Hou, Y; Jain, M; Juedes, M; Li, L; Mullarkey, T; Rocheford, E; Sung, MJ; Tyler, A; Yang, Q; Yoon, T; Hubbard, BK Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides. ACS Med Chem Lett3:411-415 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50388921 |
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| n/a |
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| Name | BDBM50388921 |
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| Synonyms: | CHEMBL2063281 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N3O4 |
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| Mol. Mass. | 443.4944 |
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| SMILES | Cc1ccc(NC(=O)c2ccc3nc([nH]c3c2)-c2c(C)cc(OCC(O)=O)cc2C)cc1C |
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| Structure | 
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