Reaction Details |
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Target | Biotin--protein ligase |
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Ligand | BDBM50388934 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_831149 (CHEMBL2065962) |
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Ki | 3500±n/a nM |
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Citation | Soares da Costa, TP; Tieu, W; Yap, MY; Zvarec, O; Bell, JM; Turnidge, JD; Wallace, JC; Booker, GW; Wilce, MC; Abell, AD; Polyak, SW Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase. ACS Med Chem Lett3:509-514 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Biotin--protein ligase |
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Name: | Biotin--protein ligase |
Synonyms: | BPL1_HUMAN | Biotin apo-protein ligase | Biotin--[acetyl-CoA-carboxylase] ligase | Biotin--[methylcrotonoyl-CoA-carboxylase] ligase | Biotin--[methylmalonyl-CoA-carboxytransferase] ligase | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase | HCS | HLCS | Holocarboxylase synthetase |
Type: | PROTEIN |
Mol. Mass.: | 80745.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1475435 |
Residue: | 726 |
Sequence: | MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEH
VGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESV
KFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFH
EVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQG
GKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSP
GRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRR
YEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSL
RFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMR
LLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPF
VQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGC
GFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVL
PLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNL
ILPKRR
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BDBM50388934 |
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n/a |
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Name | BDBM50388934 |
Synonyms: | CHEMBL2063404 |
Type | Small organic molecule |
Emp. Form. | C12H18N2OS |
Mol. Mass. | 238.349 |
SMILES | O=C1N[C@H]2CS[C@@H](CCCCCC#C)[C@H]2N1 |r| |
Structure |
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