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TargetBaculoviral IAP repeat-containing protein 3
LigandBDBM50388975
Substrate/Competitorn/a
Meas. Tech.ChEMBL_833601 (CHEMBL2066542)
Ki 43±n/a nM
Citation Flygare, JABeresini, MBudha, NChan, HChan, ITCheeti, SCohen, FDeshayes, KDoerner, KEckhardt, SGElliott, LOFeng, BFranklin, MCReisner, SFGazzard, LHalladay, JHymowitz, SGLa, HLoRusso, PMaurer, BMurray, LPlise, EQuan, CStephan, JPYoung, SGTom, JTsui, VUm, JVarfolomeev, EVucic, DWagner, AJWallweber, HJWang, LWare, JWen, ZWong, HWong, JMWong, MWong, SYu, RZobel, KFairbrother, WJ Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem55:4101-13 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Baculoviral IAP repeat-containing protein 3
Name:Baculoviral IAP repeat-containing protein 3
Synonyms:API2 | BIRC3 | BIRC3_HUMAN | Baculoviral IAP repeat-containing protein 3 | Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) | Inhibitor of apoptosis protein 3 (cIAP2) | MIHC | RNF49 | XIAP-BIR3 | cIAP1/cIAP2
Type:Protein
Mol. Mass.:68365.75
Organism:Homo sapiens (Human)
Description:Q13489
Residue:604
Sequence:
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGV
NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS
THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP
LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQ
DTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR
CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS
IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDL
LNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHD
VIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVS
DLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVR
TFLS
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BDBM50388975
n/a
NameBDBM50388975
Synonyms:CHEMBL2063869
TypeSmall organic molecule
Emp. Form.C25H34N6O3S
Mol. Mass.498.641
SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)Nc1snnc1-c1ccccc1 |r|
Structure
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