Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMax-like protein X
LigandBDBM50388969
Substrate/Competitorn/a
Meas. Tech.ChEMBL_833604
Ki 30±n/a nM
Citation Flygare JABeresini MBudha NChan HChan ITCheeti SCohen FDeshayes KDoerner KEckhardt SGElliott LOFeng BFranklin MCReisner SFGazzard LHalladay JHymowitz SGLa HLoRusso PMaurer BMurray LPlise EQuan CStephan JPYoung SGTom JTsui VUm JVarfolomeev EVucic DWagner AJWallweber HJWang LWare JWen ZWong HWong JMWong MWong SYu RZobel KFairbrother WJ Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem 55:4101-13 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Max-like protein X
Name:Max-like protein X
Synonyms:BHLHD13 | Class D basic helix-loop-helix protein 13 | MLX | Max-like bHLHZip protein | Protein BigMax | TCFL4 | Transcription factor-like protein 4 | bHLHd13
Type:PROTEIN
Mol. Mass.:33306.36
Organism:Homo sapiens (Human)
Description:ChEMBL_833604
Residue:298
Sequence:
MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCRED
SSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQE
AYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKT
IDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFN
VFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50388969
n/a
NameBDBM50388969
Synonyms:CHEMBL2063862
TypeSmall organic molecule
Emp. Form.C28H38N4O3
Mol. Mass.478.6263
SMILESCN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(c1ccccc1)c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: