| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
|---|
| Ligand | BDBM50321758 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_833107 (CHEMBL2067311) |
|---|
| Ki | 3.3±n/a nM |
|---|
| Citation |  Oberdorf, C; Schepmann, D; Vela, JM; Buschmann, H; Holenz, J; Wünsch, B Thiophene bioisosteres of spirocyclics receptor ligands: relationships between substitution pattern ands receptor affinity. J Med Chem55:5350-60 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sigma non-opioid intracellular receptor 1 |
|---|
| Name: | Sigma non-opioid intracellular receptor 1 |
|---|
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25307.17 |
|---|
| Organism: | Cavia porcellus (Guinea pig) |
|---|
| Description: | Q60492 |
|---|
| Residue: | 223 |
|---|
| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
|
|
|
|---|
| BDBM50321758 |
|---|
| n/a |
|---|
| Name | BDBM50321758 |
|---|
| Synonyms: | (R)-1,2'-dibenzyl-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] | CHEMBL1171418 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H29NO2S |
|---|
| Mol. Mass. | 419.579 |
|---|
| SMILES | CO[C@H]1Cc2sc(Cc3ccccc3)cc2C2(CCN(Cc3ccccc3)CC2)O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
