Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase PAK 4

Ligand

BDBM50389112

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_832968 (CHEMBL2066923)

2.8±n/a nM

Citation

Guo, C; McAlpine, I; Zhang, J; Knighton, DD; Kephart, S; Johnson, MC; Li, H; Bouzida, D; Yang, A; Dong, L; Marakovits, J; Tikhe, J; Richardson, P; Guo, LC; Kania, R; Edwards, MP; Kraynov, E; Christensen, J; Piraino, J; Lee, J; Dagostino, E; Del-Carmen, C; Deng, YL; Smeal, T; Murray, BW Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. J Med Chem55:4728-39 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase PAK 4

Name:

Serine/threonine-protein kinase PAK 4

Synonyms:

KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)

Type:

Protein

Mol. Mass.:

64098.01

Organism:

Homo sapiens (Human)

Description:

O96013

Residue:

591

Sequence:

MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR

BDBM50389112

n/a

Name

BDBM50389112

Synonyms:

CHEMBL2064556

Type

Small organic molecule

Emp. Form.

C37H34N8O

Mol. Mass.

606.7189

SMILES

CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccc(NCc5ccc(cc5)-c5ccccn5)cc4[nH]3)c2c1)c1ccccc1 |r|

Structure