Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase PAK 4 |
---|
Ligand | BDBM50389116 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_832968 (CHEMBL2066923) |
---|
Ki | 12±n/a nM |
---|
Citation | Guo, C; McAlpine, I; Zhang, J; Knighton, DD; Kephart, S; Johnson, MC; Li, H; Bouzida, D; Yang, A; Dong, L; Marakovits, J; Tikhe, J; Richardson, P; Guo, LC; Kania, R; Edwards, MP; Kraynov, E; Christensen, J; Piraino, J; Lee, J; Dagostino, E; Del-Carmen, C; Deng, YL; Smeal, T; Murray, BW Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. J Med Chem55:4728-39 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase PAK 4 |
---|
Name: | Serine/threonine-protein kinase PAK 4 |
Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) |
Type: | Protein |
Mol. Mass.: | 64098.01 |
Organism: | Homo sapiens (Human) |
Description: | O96013 |
Residue: | 591 |
Sequence: | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
|
|
|
BDBM50389116 |
---|
n/a |
---|
Name | BDBM50389116 |
Synonyms: | CHEMBL2064561 |
Type | Small organic molecule |
Emp. Form. | C25H29N5O3 |
Mol. Mass. | 447.5295 |
SMILES | CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccc3)[nH]nc2C1(C)C)c1ccccc1 |r| |
Structure |
|