| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50389116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_832975 (CHEMBL2067019) |
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| Ki | 2000±n/a nM |
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| Citation |  Guo, C; McAlpine, I; Zhang, J; Knighton, DD; Kephart, S; Johnson, MC; Li, H; Bouzida, D; Yang, A; Dong, L; Marakovits, J; Tikhe, J; Richardson, P; Guo, LC; Kania, R; Edwards, MP; Kraynov, E; Christensen, J; Piraino, J; Lee, J; Dagostino, E; Del-Carmen, C; Deng, YL; Smeal, T; Murray, BW Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. J Med Chem55:4728-39 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50389116 |
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| n/a |
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| Name | BDBM50389116 |
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| Synonyms: | CHEMBL2064561 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N5O3 |
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| Mol. Mass. | 447.5295 |
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| SMILES | CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)c3ccccc3)[nH]nc2C1(C)C)c1ccccc1 |r| |
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| Structure | 
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