| Reaction Details |
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 | Report a problem with these data |
| Target | NUAK family SNF1-like kinase 1 |
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| Ligand | BDBM50389154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_833222 (CHEMBL2067586) |
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| IC50 | 26±n/a nM |
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| Citation |  Gingrich, DE; Lisko, JG; Curry, MA; Cheng, M; Quail, M; Lu, L; Wan, W; Albom, MS; Angeles, TS; Aimone, LD; Haltiwanger, RC; Wells-Knecht, K; Ott, GR; Ghose, AK; Ator, MA; Ruggeri, B; Dorsey, BD Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem55:4580-93 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NUAK family SNF1-like kinase 1 |
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| Name: | NUAK family SNF1-like kinase 1 |
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| Synonyms: | ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74326.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1451343 |
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| Residue: | 661 |
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| Sequence: | MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
N
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| BDBM50389154 |
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| n/a |
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| Name | BDBM50389154 |
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| Synonyms: | CHEMBL2064666 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35ClN6O3 |
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| Mol. Mass. | 539.069 |
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| SMILES | COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1 |r,c:16| |
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| Structure | 
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