| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM50389224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_831542 (CHEMBL2066306) |
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| IC50 | 170±n/a nM |
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| Citation |  Hsu, JT; Yeh, TK; Yen, SC; Chen, CT; Hsieh, SY; Hsu, T; Lu, CT; Chen, CH; Chou, LH; Chiu, CH; Chang, YI; Tseng, YJ; Yen, KR; Chao, YS; Lin, WH; Jiaang, WT 3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorg Med Chem Lett22:4654-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM50389224 |
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| n/a |
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| Name | BDBM50389224 |
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| Synonyms: | CHEMBL2063338 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34N8O3 |
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| Mol. Mass. | 542.6321 |
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| SMILES | Cc1nc(Nc2cc(n[nH]2)-c2ccc(CNC(=O)OCc3ccccc3)cc2)cc(n1)N1CCN(CCO)CC1 |
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| Structure | 
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