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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50389530 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_832416 (CHEMBL2067140) | ||
| IC50 | 24±n/a nM | ||
| Citation |  Takeda, K; Terauchi, T; Hashizume, M; Shin, K; Ino, M; Shibata, H; Yonaga, M Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists. Bioorg Med Chem Lett22:5372-8 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50389530 | |||
| n/a | |||
| Name | BDBM50389530 | ||
| Synonyms: | CHEMBL2063372 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H32N2O3 | ||
| Mol. Mass. | 408.5332 | ||
| SMILES | CCN(CC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(9.62,-11.23,;10.96,-12,;10.96,-13.54,;12.3,-14.3,;12.3,-15.84,;9.63,-14.31,;8.3,-13.55,;6.97,-14.32,;6.96,-15.86,;5.63,-16.63,;8.3,-16.63,;8.29,-18.17,;9.63,-18.94,;10.97,-18.17,;12.3,-18.93,;10.97,-16.63,;9.64,-15.86,;9.63,-20.48,;8.29,-21.25,;6.96,-20.48,;5.63,-21.25,;8.29,-22.79,;9.63,-23.56,;9.63,-25.1,;8.3,-25.87,;6.96,-25.1,;10.97,-22.78,;10.96,-21.24,;12.29,-20.47,;13.63,-21.24,)| | ||
| Structure | 
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