| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Ligand | BDBM50365964 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_834693 (CHEMBL2072669) |
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| Ki | 1.18±n/a nM |
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| Citation |  Hu, E; Ma, J; Biorn, C; Lester-Zeiner, D; Cho, R; Rumfelt, S; Kunz, RK; Nixey, T; Michelsen, K; Miller, S; Shi, J; Wong, J; Hill Della Puppa, G; Able, J; Talreja, S; Hwang, DR; Hitchcock, SA; Porter, A; Immke, D; Allen, JR; Treanor, J; Chen, H Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer. J Med Chem55:4776-87 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
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| Synonyms: | PDE10_RAT | Pde10a | Phosphodiesterase 10 | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase Type 10 (PDE10A) | Rat recombinant PDE10a (rPDE10a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 90160.88 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | PDE10A was generated from the full-length recombinant rat clone transfected into Sf9 cells. |
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| Residue: | 794 |
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| Sequence: | MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKAEDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD
GFALYFLGECNNSLCVFTPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMHFNLPARICRDIELFHFDIG
PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPAT
SKSTSEKPTRKVDD
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| BDBM50365964 |
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| n/a |
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| Name | BDBM50365964 |
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| Synonyms: | CHEMBL1956235 | CHEMBL2070530 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N4O2 |
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| Mol. Mass. | 338.4036 |
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| SMILES | COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC |
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| Structure | 
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