Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSigma non-opioid intracellular receptor 1
LigandBDBM50324097
Substrate/Competitorn/a
Meas. Tech.ChEMBL_834660 (CHEMBL2072546)
Ki 0.18±n/a nM
Citation Moussa, IABanister, SDManoli, MDoddareddy, MRCui, JMach, RHKassiou, M Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity. Bioorg Med Chem Lett22:5493-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:Protein
Mol. Mass.:25307.17
Organism:Cavia porcellus (Guinea pig)
Description:Q60492
Residue:223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50324097
n/a
NameBDBM50324097
Synonyms:CHEMBL1214831 | N-(Benzofuran-2-ylmethyl)-N'-(4'-ethoxybenzyl)piperazine
TypeSmall organic molecule
Emp. Form.C22H26N2O2
Mol. Mass.350.454
SMILESCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: