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TargetMethylthioadenosine Phosphorylase (MTAP)
LigandBDBM50390252
Substrate/Competitorn/a
Meas. Tech.ChEMBL_834947
Ki 105±n/a nM
Citation Clinch KEvans GBFröhlich RFGulab SAGutierrez JAMason JMSchramm VLTyler PCWoolhouse AD Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. Bioorg Med Chem 20:5181-7 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Methylthioadenosine Phosphorylase (MTAP)
Name:Methylthioadenosine Phosphorylase (MTAP)
Synonyms:5'-Methylthioadenosine phosphorylase (MTAP) | MTA phosphorylase | MTAPase | S-methyl-5 -thioadenosine phosphorylase
Type:Enzyme
Mol. Mass.:31239.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
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  Blast E-value cutoff:
BDBM50390252
n/a
NameBDBM50390252
Synonyms:CHEMBL2070406
TypeSmall organic molecule
Emp. Form.C14H23N5O2S
Mol. Mass.325.43
SMILESCSC[C@H](O)[C@@H](CO)CN(C)Cc1c[nH]c2c(N)ncnc12 |r|
Structure
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