| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Ligand | BDBM50390324 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835072 (CHEMBL2073616) |
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| IC50 | 6.8±n/a nM |
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| Citation |  DeNinno, MP; Wright, SW; Etienne, JB; Olson, TV; Rocke, BN; Corbett, JW; Kung, DW; DiRico, KJ; Andrews, KM; Millham, ML; Parker, JC; Esler, W; van Volkenburg, M; Boyer, DD; Houseknecht, KL; Doran, SD Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg Med Chem Lett22:5721-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
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| Synonyms: | PDE8B | PDE8B_HUMAN | Phosphodiesterase 8 | Phosphodiesterase 8B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98984.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_876321 |
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| Residue: | 885 |
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| Sequence: | MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
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| BDBM50390324 |
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| n/a |
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| Name | BDBM50390324 |
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| Synonyms: | CHEMBL2070604 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N8 |
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| Mol. Mass. | 296.3304 |
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| SMILES | Nc1nc(nc2n(Cc3cc(n[nH]3)C3CC3)nnc12)C1CC1 |
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| Structure | 
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