| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphatidylinositol 4-kinase beta |
|---|
| Ligand | BDBM50390409 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_834242 (CHEMBL2073009) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Bruce, I; Akhlaq, M; Bloomfield, GC; Budd, E; Cox, B; Cuenoud, B; Finan, P; Gedeck, P; Hatto, J; Hayler, JF; Head, D; Keller, T; Kirman, L; Leblanc, C; Le Grand, D; McCarthy, C; O'Connor, D; Owen, C; Oza, MS; Pilgrim, G; Press, NE; Sviridenko, L; Whitehead, L Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorg Med Chem Lett22:5445-50 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphatidylinositol 4-kinase beta |
|---|
| Name: | Phosphatidylinositol 4-kinase beta |
|---|
| Synonyms: | NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 91373.30 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 816 |
|---|
| Sequence: | MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
|
|
|
|---|
| BDBM50390409 |
|---|
| n/a |
|---|
| Name | BDBM50390409 |
|---|
| Synonyms: | CHEMBL1986603 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N7O3S |
|---|
| Mol. Mass. | 451.502 |
|---|
| SMILES | Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(s2)-c2ccc(cc2)-n2cccn2)no1 |
|---|
| Structure | 
|
|---|
Search and Browse
