| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50390495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835301 (CHEMBL2072007) |
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| IC50 | 5490±n/a nM |
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| Citation |  Hua, Z; Huang, X; Bregman, H; Chakka, N; DiMauro, EF; Doherty, EM; Goldstein, J; Gunaydin, H; Huang, H; Mercede, S; Newcomb, J; Patel, VF; Turci, SM; Yan, J; Wilson, C; Martin, MW 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1¿) inhibitors. Bioorg Med Chem Lett22:5392-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 38936.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48729 |
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| Residue: | 337 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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| BDBM50390495 |
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| n/a |
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| Name | BDBM50390495 |
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| Synonyms: | CHEMBL2071609 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14N4 |
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| Mol. Mass. | 310.352 |
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| SMILES | N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1 |
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| Structure | 
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