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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50390709
Substrate/Competitorn/a
Meas. Tech.ChEMBL_835662 (CHEMBL2071773)
IC50 12±n/a nM
Citation Valeur, EChristmann-Franck, SLepifre, FCarniato, DCravo, DCharon, CBozec, SMusil, DHillertz, PDoare, LSchmidlin, FLecomte, MSchultz, MRoche, D Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett22:5909-14 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50390709
n/a
NameBDBM50390709
Synonyms:CHEMBL2070318
TypeSmall organic molecule
Emp. Form.C22H24ClN3O
Mol. Mass.381.898
SMILESCc1[nH]c2ncccc2c1C1CCN(C1)C(=O)C(C)(C)c1ccc(Cl)cc1
Structure
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