| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50327390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835729 (CHEMBL2071840) |
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| IC50 | 4±n/a nM |
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| Citation |  He, L; Seitz, SP; Trainor, GL; Tortolani, D; Vaccaro, W; Poss, M; Tarby, CM; Tokarski, JS; Penhallow, B; Hung, CY; Attar, R; Lin, TA Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett22:5995-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50327390 |
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| n/a |
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| Name | BDBM50327390 |
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| Synonyms: | 5-(6-(2-chlorophenyl)-2-(pyridin-2-yl)pyrimidin-4-yl)-N-isopropylthiazol-2-amine | CHEMBL1258633 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClN5S |
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| Mol. Mass. | 407.919 |
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| SMILES | CC(C)Nc1ncc(s1)-c1cc(nc(n1)-c1ccccn1)-c1ccccc1Cl |
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| Structure | 
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