| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity testis-specific protein kinase 2 |
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| Ligand | BDBM50390777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835732 (CHEMBL2071843) |
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| IC50 | >30000±n/a nM |
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| Citation |  He, L; Seitz, SP; Trainor, GL; Tortolani, D; Vaccaro, W; Poss, M; Tarby, CM; Tokarski, JS; Penhallow, B; Hung, CY; Attar, R; Lin, TA Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett22:5995-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity testis-specific protein kinase 2 |
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| Name: | Dual specificity testis-specific protein kinase 2 |
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| Synonyms: | TESK2 | TESK2_HUMAN | Testicular protein kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63642.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_835732 |
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| Residue: | 571 |
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| Sequence: | MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
EMEVEERPAGSTPATFSTSGIGLQTQGKQDG
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| BDBM50390777 |
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| n/a |
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| Name | BDBM50390777 |
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| Synonyms: | CHEMBL2070495 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClN6OS |
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| Mol. Mass. | 495.039 |
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| SMILES | CCCNc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1ccc(OC(CC)CC)cc1Cl |
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| Structure | 
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