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TargetPotassium voltage-gated channel subfamily KQT member 1
LigandBDBM50390872
Substrate/Competitorn/a
Meas. Tech.ChEMBL_835825 (CHEMBL2071936)
EC50 880±n/a nM
Citation Mattmann, MEYu, HLin, ZXu, KHuang, XLong, SWu, MMcManus, OBEngers, DWLe, UMLi, MLindsley, CWHopkins, CR Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett22:5936-41 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily KQT member 1
Name:Potassium voltage-gated channel subfamily KQT member 1
Synonyms:KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1
Type:PROTEIN
Mol. Mass.:74739.00
Organism:Homo sapiens (Human)
Description:ChEMBL_1454245
Residue:676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50390872
n/a
NameBDBM50390872
Synonyms:CHEMBL2070964
TypeSmall organic molecule
Emp. Form.C23H22N4O4S2
Mol. Mass.482.575
SMILESCOc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C#N)n1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: