Reaction Details |
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Target | Potassium voltage-gated channel subfamily KQT member 4 |
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Ligand | BDBM50390916 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_835828 (CHEMBL2071939) |
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EC50 | >30000±n/a nM |
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Citation | Mattmann, ME; Yu, H; Lin, Z; Xu, K; Huang, X; Long, S; Wu, M; McManus, OB; Engers, DW; Le, UM; Li, M; Lindsley, CW; Hopkins, CR Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett22:5936-41 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily KQT member 4 |
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Name: | Potassium voltage-gated channel subfamily KQT member 4 |
Synonyms: | KCNQ (Kv7) potassium channel | KCNQ4 | KCNQ4_HUMAN | KQT-like 4 | Potassium channel subunit alpha KvLQT4 | Potassium voltage-gated channel subfamily KQT member 4 | Voltage-gated potassium channel subunit Kv7.4 |
Type: | PROTEIN |
Mol. Mass.: | 77131.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1520985 |
Residue: | 695 |
Sequence: | MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
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BDBM50390916 |
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n/a |
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Name | BDBM50390916 |
Synonyms: | CHEMBL2070953 |
Type | Small organic molecule |
Emp. Form. | C23H25N3O4S2 |
Mol. Mass. | 471.592 |
SMILES | COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r| |
Structure |
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