Reaction Details |
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Target | Potassium voltage-gated channel subfamily KQT member 1 |
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Ligand | BDBM50390924 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_835825 (CHEMBL2071936) |
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EC50 | >30000±n/a nM |
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Citation | Mattmann, ME; Yu, H; Lin, Z; Xu, K; Huang, X; Long, S; Wu, M; McManus, OB; Engers, DW; Le, UM; Li, M; Lindsley, CW; Hopkins, CR Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett22:5936-41 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily KQT member 1 |
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Name: | Potassium voltage-gated channel subfamily KQT member 1 |
Synonyms: | KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
Type: | PROTEIN |
Mol. Mass.: | 74739.00 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1454245 |
Residue: | 676 |
Sequence: | MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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BDBM50390924 |
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n/a |
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Name | BDBM50390924 |
Synonyms: | CHEMBL2070956 |
Type | Small organic molecule |
Emp. Form. | C26H31N3O4S2 |
Mol. Mass. | 513.672 |
SMILES | COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(C)(C)C)n1 |r| |
Structure |
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