| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50391023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_840426 (CHEMBL2089603) |
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| IC50 | 1.2±n/a nM |
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| Citation |  Cherney, RJ; Mo, R; Meyer, DT; Pechulis, AD; Guaciaro, MA; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Cvijic, ME; Barrish, JC; Decicco, CP; Carter, PH Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett22:6181-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50391023 |
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| n/a |
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| Name | BDBM50391023 |
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| Synonyms: | CHEMBL2088388 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35F3N4O3S |
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| Mol. Mass. | 576.673 |
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| SMILES | CC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N1CCC(C1=O)c1nc2cccc(c2[nH]1)C(F)(F)F |r| |
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| Structure | 
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