| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Ligand | BDBM50391350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_847915 (CHEMBL2150114) |
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| IC50 | 28±n/a nM |
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| Citation |  Miyahara, S; Miyakoshi, H; Yokogawa, T; Chong, KT; Taguchi, J; Muto, T; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Nomura, M; Nagasawa, H; Shuto, S; Fukuoka, M Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy. J Med Chem55:5483-96 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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| Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
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| Type: | Enzyme |
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| Mol. Mass.: | 26574.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33316 |
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| Residue: | 252 |
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| Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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| BDBM50391350 |
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| n/a |
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| Name | BDBM50391350 |
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| Synonyms: | CHEMBL2147979 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N3O5S |
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| Mol. Mass. | 447.548 |
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| SMILES | CC(C)(CC\C=C\Cn1ccc(=O)[nH]c1=O)NS(=O)(=O)c1cccc(OCC2CC2)c1 |
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| Structure | 
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