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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM50391375
Substrate/Competitorn/a
Meas. Tech.ChEMBL_847930 (CHEMBL2150230)
IC50 110±n/a nM
Citation Röhrig, UFMajjigapu, SRGrosdidier, ABron, SStroobant, VPilotte, LColau, DVogel, PVan den Eynde, BJZoete, VMichielin, O Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem55:5270-90 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase 1
Synonyms:I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase
Type:PROTEIN
Mol. Mass.:45639.39
Organism:Mus musculus
Description:ChEMBL_1452149
Residue:407
Sequence:
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLR
EEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSE
KLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASP
AIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSG
WKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMR
EYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMK
PSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
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  Blast E-value cutoff:
BDBM50391375
n/a
NameBDBM50391375
Synonyms:CHEMBL2147993
TypeSmall organic molecule
Emp. Form.C8H6N4O2
Mol. Mass.190.1588
SMILES[O-][N+](=O)c1cccc(c1)-c1c[nH]nn1
Structure
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