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TargetCarbonic anhydrase 12
LigandBDBM50387127
Substrate/Competitorn/a
Meas. Tech.ChEMBL_847943 (CHEMBL2150243)
Ki 7±n/a nM
Citation Gieling, RGBabur, MMamnani, LBurrows, NTelfer, BACarta, FWinum, JYScozzafava, ASupuran, CTWilliams, KJ Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem55:5591-600 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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  Blast E-value cutoff:
BDBM50387127
n/a
NameBDBM50387127
Synonyms:4-ureidophenyl sulfamate ring derivative 3l | CHEMBL2047807
TypeSmall organic molecule
Emp. Form.C15H17N3O4S
Mol. Mass.335.378
SMILESNS(=O)(=O)Oc1ccc(NC(=O)NCCc2ccccc2)cc1
Structure
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